Azilsartan medoxomil monopotassium (TAK 491)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$950	Check With Us
1g	$1350	Check With Us
5g	$3645	Check With Us

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Cat #: V29052 CAS #: 863031-24-7 Purity ≥ 99%

Description: Azilsartan medoxomil monopotassium (TAK-491; TAK491; Edarbi), the monopotassium salt of Azilsartan medoxomil which is a prodrug of azilsartan, is an angiotensin II receptor (AT1) type 1 antagonist approved as an anti-hypertensive medication to lower blood pressure.

References: Kajiya T, Ho C, Wang J, Molecular and cellular effects of azilsartan: a new generation angiotensin II receptor blocker. J Hypertens. 2011 Dec;29(12):2476-83.

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Molecular Weight (MW)	606.62
Molecular Formula	C30H23KN4O8
CAS No.	863031-24-7

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.6485 mL	8.2424 mL	16.4848 mL	32.9696 mL
5mM	0.3297 mL	1.6485 mL	3.2970 mL	6.5939 mL
10mM	0.1648 mL	0.8242 mL	1.6485 mL	3.2970 mL
20mM	0.0824 mL	0.4121 mL	0.8242 mL	1.6485 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.