AVE-0991 sodium
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1550 | To Be Confirmed |
| 200mg | $2325 | To Be Confirmed |
| 500mg | $3500 | To Be Confirmed |
: Cat #: V11930 CAS #: 306288-04-0 Purity ≥ 98%
Description: AVE0991 sodium, the sodium salt of AVE-0991, is a novel, orally bioactive non-peptide mimic and high affinity agonist of angiotensin-(1-7) with an IC50 of 21 nM.
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| Molecular Weight (MW) | 602.70 |
|---|---|
| Molecular Formula | C29H31N4NaO5S2 |
| CAS No. | 306288-04-0 |
| Protocol | In Vitro | AVE 0991 is a nonpeptide compound that evokes effects similar to Ang-(1-7) on the endothelium. AVE 0991 and unlabeled Ang-(1-7) compete for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC50s of 21±35 and 220±280 nM, respectively. Peak concentrations of NO and O2- release by AVE 0991 sodium salt and Ang-(1-7) (both 10 μM) are not significantly different (NO: 295±20 and 270±25 nM; O2-: 18±2 and 20±4 nM). However, the released amount of bioactive NO is ≈5 times higher for AVE 0991 in comparison to Ang-(1-7) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6592 mL | 8.2960 mL | 16.5920 mL | 33.1840 mL |
| 5mM | 0.3318 mL | 1.6592 mL | 3.3184 mL | 6.6368 mL |
| 10mM | 0.1659 mL | 0.8296 mL | 1.6592 mL | 3.3184 mL |
| 20mM | 0.0830 mL | 0.4148 mL | 0.8296 mL | 1.6592 mL |
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.