Eprosartan (SKF-108566J)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$350	Check With Us
1g	$550	Check With Us
5g	$1485	Check With Us

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Cat #: V19995 CAS #: 133040-01-4 Purity ≥ 99%

Description: Eprosartan (formerly SKF-108566J; SKF108566; SKF 108566; Teveten; Futuran; Navixen; Regulaten) is a nonpeptide angiotensin II receptor antagonist that has been approved as an antihypertensive medication for the treatment of high blood pressure.

References: R M Edwards, et al. Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J Pharmacol Exp Ther. 1992 Jan;260(1):175-81.

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Physicochemical and Storage Information
Protocol
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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	424.51
Molecular Formula	C23H24N2O4S
CAS No.	133040-01-4

Protocol	In Vitro	Eprosartan (SKF-108566J) inhibits [125I]AII binding to human liver membranes (IC50 of 1.7 nM) and to rat mesenteric artery membranes (IC50 of 1.5 nM). In rabbit aortic smooth muscle cells, Eprosartan caused a concentration-dependent inhibition of AII-induced increases in intracellular Ca2+ levels
Protocol	In Vivo	In conscious normotensive rats, i.v. administration of Eprosartan (0.01-0.3 mg/kg) produced dose-dependent parallel shifts in the AII pressor dose-response curve. Administration of Eprosartan (3-10 mg/kg) intraduodenally or intragastrically to conscious normotensive rats resulted in a dose-dependent inhibition of the pressor response to AII (250 ng/kg, i.v.). At 10 mg/kg, i.d., significant inhibition of the pressor response to AII was observed for 3 hr

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3557 mL	11.7783 mL	23.5566 mL	47.1131 mL
5mM	0.4711 mL	2.3557 mL	4.7113 mL	9.4226 mL
10mM	0.2356 mL	1.1778 mL	2.3557 mL	4.7113 mL
20mM	0.1178 mL	0.5889 mL	1.1778 mL	2.3557 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.