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Losartan (DUP 89)

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Losartan (DUP 89)
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100g$950Check With Us
200g$1650Check With Us
500g$2550Check With Us
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Cat #: V24404 CAS #: 114798-26-4 Purity ≥ 99%

Description: Losartan (DuP-753) is a potent, selective, and non-peptide angiotensin II receptor antagonist, it competes with angiotensin II for binding to AT1 receptors with IC50 of 20 nM.

References: Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103(6): p. 904-12.

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Molecular Weight (MW)422.91
Molecular FormulaC22H23ClN6O
CAS No.114798-26-4
ProtocolIn VitroLosartan competes with the binding of angiotensin II to AT1 receptors. The concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20 nM
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3646 mL11.8228 mL23.6457 mL47.2914 mL
5mM0.4729 mL2.3646 mL4.7291 mL9.4583 mL
10mM0.2365 mL1.1823 mL2.3646 mL4.7291 mL
20mM0.1182 mL0.5911 mL1.1823 mL2.3646 mL
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.