CYM-50308
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1250 | To Be Confirmed |
| 100mg | $1950 | To Be Confirmed |
| 200mg | $2925 | To Be Confirmed |
: Cat #: V18990 CAS #: 1345858-76-5 Purity ≥ 99%
Description: CYM-50308 (CYM50308; ML248; ML-248) is a novel and potent agonist of SIP4 (sphingosine-1-phosphate receptor 4) (EC50 = 56 nM).
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| Molecular Weight (MW) | 405.46 |
|---|---|
| Molecular Formula | C20H21F2N3O2S |
| CAS No. | 1345858-76-5 |
| Protocol | In Vitro | The disclosed lead molecule CYM50308 (Compound 24f) displays low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. Noteworthy, CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4663 mL | 12.3317 mL | 24.6633 mL | 49.3267 mL |
| 5mM | 0.4933 mL | 2.4663 mL | 4.9327 mL | 9.8653 mL |
| 10mM | 0.2466 mL | 1.2332 mL | 2.4663 mL | 4.9327 mL |
| 20mM | 0.1233 mL | 0.6166 mL | 1.2332 mL | 2.4663 mL |
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.