BAY 41-2272
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1550 | Check With Us |
| 500mg | $2550 | Check With Us |
| 1g | $3825 | Check With Us |
: Cat #: V1869 CAS #: 256376-24-6 Purity ≥ 98%
Description: BAY 41-2272 is a novel and potent activator of nitric oxide-sensitive guanylyl cyclase (NO-sensitive GC) with EC50 values of 0.3 μmol/L and 3 μmol/L in the presence and absence of 100 nmol/L DEA-NO, respectively.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 360.39 |
|---|---|
| Molecular Formula | C20H17FN6 |
| CAS No. | 256376-24-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 35 mg/mL (97.1 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 4 mg/mL (11.09 mM) | |
| Synonyms | BAY 41-2272; BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272 |
| Protocol | In Vivo | BAY 41-2272 (0.3-3 mg/kg; p.o.; single dose; monitored for 12 h) has inhibitory effect in hypertensive dog |
|---|---|---|
| Animal model | Hypertensive beagle dogs | |
| Dosages | 0.3 mg/kg, 1 mg/kg, 3 mg/kg | |
| Administration | Oral gavage; single dose; monitored for 12 hr |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7748 mL | 13.8739 mL | 27.7477 mL | 55.4954 mL |
| 5mM | 0.5550 mL | 2.7748 mL | 5.5495 mL | 11.0991 mL |
| 10mM | 0.2775 mL | 1.3874 mL | 2.7748 mL | 5.5495 mL |
| 20mM | 0.1387 mL | 0.6937 mL | 1.3874 mL | 2.7748 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.