PLECANATIDE | CAS 467426-54-6

PLECANATIDE

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
50mg	$1650	To Be Confirmed
100mg	$2750	To Be Confirmed
200mg	$4125	To Be Confirmed

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Cat #: V3934 CAS #: 467426-54-6 Purity ≥ 98%

Description: Plecanatide (Trade name Trulance; formerly SP304; SP-304), a 16 amino acid peptide and a synthetic analog of uroguanylin, is a drug approved by FDA for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation.

References: Shailubhai K,et, al. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015 Nov 6;6(4):213-22.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	1681.89
Molecular Formula	C65H104N18O26S4
CAS No.	467426-54-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: >10mMr
	Water: >10mMr
	Ethanol: N/A
SMILES Code	CC1C(=O)NC2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)CNC(=O)C(NC2=O)C(C)O)C(=O)NC(CC(C)C)C(=O)O)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1) C(C)C)CC(=O)N)C(C)C)CC(C)C)CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)N)N
Synonyms	SP-304; SP 304; SP304; Trulance

Protocol	In Vitro	Plecanatide (1 nM-10 μM) activates GC-C receptor to stimulate cyclic guanosine monophosphate (cGMP) synthesis in a dose-dependent manner with EC50 of 190 nM in T84 cells
	In Vivo	Plecanatide (0.5 and 2.5 mg/kg, p.o.) ameliorates spontaneous and chemically induced colitis after treatment for 7 days in BALB/c mice, and 14 days in TCRα-/- mice
	Animal model	Female BALB/c mice (2-4 month old) are induced colitis by TNBS
	Dosages	0, 0.5 and 2.5 mg/kg
	Administration	P.o. for 7 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.5946 mL	2.9728 mL	5.9457 mL	11.8914 mL
5mM	0.1189 mL	0.5946 mL	1.1891 mL	2.3783 mL
10mM	0.0595 mL	0.2973 mL	0.5946 mL	1.1891 mL
20mM	0.0297 mL	0.1486 mL	0.2973 mL	0.5946 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.