Home > Signaling Pathways>Neuronal Signaling>Opioid Receptor >(+)-Matrine (Vegard）
(+)-Matrine (Vegard）

This product is for research use only, not for human use. We do not sell to patients.

(+)-Matrine (Vegard）
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$250Check With Us
1g$450Check With Us
5g$1170Check With Us
email: [email protected]        [email protected]

Cat #: V1279 CAS #: 519-02-8 Purity ≥ 98%

Description: Matrine (Vegard; α-Matrine; Matridin-15-one; NSC-146051; NSC146051; (+)-Matrine) is a naturally occuring alkaloid found in plants from the Sophora family.

References: Lu Yuan, et al. Matrine alleviates cisplatin‐induced acute kidney injury by inhibiting mitochondrial dysfunction and inflammation via SIRT3/OPA1 pathway. J Cell Mol Med v.26(13); 2022 Jul.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)248.36
Molecular FormulaC15H24N2O
CAS No.519-02-8
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 49 mg/mL (197.3 mM)r
Water: 11 mg/mL (44.29 mM)r
Ethanol: 49 mg/mL (197.3 mM)
Solubility In VivoChemical Name: (41S,7aS,13aR,13bR)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one InChi Key: ZSBXGIUJOOQZMP-JLNYLFASSA-N InChi Code: InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1 SMILES Code: O=C1CCC[C@@H]2[C@H]3CCCN4CCC[C@H]([C@@H]34)CN12
SynonymsVegard; α-Matrine; Matridin-15-one; NSC 146051; NSC146051; Matrine; NSC-146051;
ProtocolIn VitroMatrine (10 μM, 48 h) inhibits cisplatin-induced oxidative injury and inflammation in HK2 cells by reducing ROS level and pro-inflammatory cytokines including IL-1β, IL-6 and TNF-α
In VivoMatrine (Intraperitoneal injections, 5 mg/kg, daily for four continuous days) attenuates renal injury and apoptosis in cisplatin-induced AKI mice, as well as reducing inflammatory responses and activating SIRT3/OPA1 axis and rescues renal mitochondrial dysfunction
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.0264 mL20.1321 mL40.2641 mL80.5283 mL
5mM0.8053 mL4.0264 mL8.0528 mL16.1057 mL
10mM0.4026 mL2.0132 mL4.0264 mL8.0528 mL
20mM0.2013 mL1.0066 mL2.0132 mL4.0264 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.