Difelikefalin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1550 | To Be Confirmed |
| 100mg | $2325 | To Be Confirmed |
| 200mg | $3485 | To Be Confirmed |
: Cat #: V19863 CAS #: 1024828-77-0 Purity ≥ 99%
Description: Difelikefalin (MR-13A9; CR-845; MR-13A-9; trade name Korsuva) is a novel, peripherally specific, and potent kappa opioid receptor agonist approved in 2021 as an analgesic opiod peptide for the treatment of moderate-to-severe itching.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 679.85 |
|---|---|
| Molecular Formula | C36H53N7O6 |
| CAS No. | 1024828-77-0 |
| Protocol | In Vitro | Difelikefalin (CR-845; FE-202845) does not penetrate the blood-brain barrier. Difelikefalin does not bind to mu opioid receptors or any other receptors beside KORs |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.4709 mL | 7.3546 mL | 14.7091 mL | 29.4183 mL |
| 5mM | 0.2942 mL | 1.4709 mL | 2.9418 mL | 5.8837 mL |
| 10mM | 0.1471 mL | 0.7355 mL | 1.4709 mL | 2.9418 mL |
| 20mM | 0.0735 mL | 0.3677 mL | 0.7355 mL | 1.4709 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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Concentration(final)
C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.