Brompheniramine maleate

This product is for research use only, not for human use. We do not sell to patients.

Brompheniramine maleate
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5g$299Check With Us
10g$450Check With Us
20g$675Check With Us

Cat #: V1231 CAS #: 980-71-2 Purity ≥ 98%

Description: Brompheniramine (Bromfed, Dimetapp, Bromfenex, Dimetane, BPN, Lodrane), the maleate salt of Brompheniramine which is an OTC drug for cold and allergic rhinitis, is a first-generation antagonist of the histamine H1 receptors.

References: Chong-Chi Chiu, et al. Subcutaneous brompheniramine for cutaneous analgesia in rats. Eur J Pharmacol. 2019 Oct 5;860:172544.

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Molecular Weight (MW)435.31
Molecular FormulaC16H19BrN2.C4H4
CAS No.980-71-2
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 87 mg/mL (199.9 mM)r
Water: 46 mg/mL (105.7 mM)r
Ethanol: 18 mg/mL (41.3 mM)
SynonymsBromfed, Dimetapp, Brompheniramine, Bromfenex, Dimetane, BPN, Lodrane
ProtocolIn VivoBrompheniramine (0.3-3 μM; SC, single dosage) induces cutaneous analgesia in rats
Animal modelMale Sprague-Dawley rats
Dosages0.3, 0.6, 1.1, 1.5 and 3.0  μM
AdministrationSC, single dosage
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2972 mL11.4861 mL22.9721 mL45.9443 mL
5mM0.4594 mL2.2972 mL4.5944 mL9.1889 mL
10mM0.2297 mL1.1486 mL2.2972 mL4.5944 mL
20mM0.1149 mL0.5743 mL1.1486 mL2.2972 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.