JNJ-7777120
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1150 | Check With Us |
| 1g | $1725 | Check With Us |
: Cat #: V1239 CAS #: 459168-41-3 Purity ≥ 98%
Description: JNJ-7777120 (JNJ7777120; JNJ 7777120), an indole analog, is a potent and selective non-imidazole-based histamine H4R receptor antagonist that can reduce allergic and asthmatic symptoms.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 277.75 |
|---|---|
| Molecular Formula | C14H16ClN3O |
| CAS No. | 459168-41-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 56 mg/mL (201.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 8 mg/mL (28.8 mM) | |
| Solubility In Vivo | 30% Propylene glycol, 5% Tween 80, 65% D5W: 20 mg/mL |
| Synonyms | JNJ7777120; JNJ-7777120; JNJ 7777120 |
| Protocol | In Vitro | JNJ-7777120 (0, 10, 100, 1000 nM; ~6 h) shows functional antagonism of the human and mouse histamine H4 receptors in SK-N-MC cells |
|---|---|---|
| In Vivo | JNJ-7777120 shows equipotent against the human, mouse, and rat receptors and exhibits at least 1000-fold selectivity over H1, H2, or H3 receptors | |
| Animal model | BALB/c mice | |
| Formulation | 20 mg/kg | |
| Administration | Subcutaneous injection; single daily for 2 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6004 mL | 18.0018 mL | 36.0036 mL | 72.0072 mL |
| 5mM | 0.7201 mL | 3.6004 mL | 7.2007 mL | 14.4014 mL |
| 10mM | 0.3600 mL | 1.8002 mL | 3.6004 mL | 7.2007 mL |
| 20mM | 0.1800 mL | 0.9001 mL | 1.8002 mL | 3.6004 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.