Desloratadine (Sch34117)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$480	Check With Us
2g	$800	Check With Us
5g	$1210	Check With Us

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Cat #: V1242 CAS #: 100643-71-8 Purity ≥ 98%

Description: Desloratadine (formerly SCH34117, NSC 675447; SCH-34117, NSC-675447; Clarinex; Neoclarityn; Descarboethoxyloratadine; Aerius) is the active metabolite of loratadine which is an anti-histamine drug of the tricyclic class used to treat allergies.

References: Geha, R.S. and E.O. Meltzer, Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol, 2001. 107(4): p. 751-62.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	310.82
Molecular Formula	C19H19ClN2
CAS No.	100643-71-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 26 mg/mL (83.6 mM)r
	Water: <1 mg/mLr
	Ethanol: 62 mg/mL (199.5 mM)
Solubility In Vivo	30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
Synonyms	SCH34117, NSC675447; SCH 34117, NSC 675447; SCH-34117, NSC-675447; Desloratadine; Clarinex; Neoclarityn; Descarboethoxyloratadine; Aerius

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.2173 mL	16.0865 mL	32.1730 mL	64.3459 mL
5mM	0.6435 mL	3.2173 mL	6.4346 mL	12.8692 mL
10mM	0.3217 mL	1.6086 mL	3.2173 mL	6.4346 mL
20mM	0.1609 mL	0.8043 mL	1.6086 mL	3.2173 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.