Lafutidine (FRG-8813)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $250 | Check With Us |
| 2g | $420 | Check With Us |
| 5g | $630 | Check With Us |
: Cat #: V1235 CAS #: 118288-08-7 Purity ≥ 98%
Description: Lafutidine (formerly FRG-8813; FRG8813; trade name: Protecadin; Stogar) is a 2nd-generation histamine H2 receptor antagonist used to treat gastric ulcers, duodenal ulcers, and wounds in the stomach associated with chronic gastritis.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 431.55 |
|---|---|
| Molecular Formula | C22H29N3O4S |
| CAS No. | 118288-08-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 86 mg/mL (199.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 13 mg/mL (30.1 mM) | |
| Synonyms | FRG-8813; Lafutidine; FRG8813; FRG 8813; trade name: Protecadin; Stogar. |
| Protocol | In Vivo | Lafutidine (3-30 mg/kg; p.o.; twice daily; for 6 days) dose-dependently reduces the severity of dextran sulfate Na (DSS)-induced colitis and significantly mitigates changes in the colon length and myeloperoxidase (MPO) activity |
|---|---|---|
| Animal model | Male Wistar rats (180-200 g) | |
| Dosages | Male Wistar rats (180-200 g) | |
| Administration | Oral administration, twice daily, for 6 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3172 mL | 11.5861 mL | 23.1723 mL | 46.3446 mL |
| 5mM | 0.4634 mL | 2.3172 mL | 4.6345 mL | 9.2689 mL |
| 10mM | 0.2317 mL | 1.1586 mL | 2.3172 mL | 4.6345 mL |
| 20mM | 0.1159 mL | 0.5793 mL | 1.1586 mL | 2.3172 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.