Ketotifen Fumarate (HC 20511)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$200	Check With Us
10g	$320	Check With Us
20g	$480	Check With Us

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Cat #: V1233 CAS #: 34580-14-8 Purity ≥ 98%

Description: Ketotifen Fumarate (HC20511; Ketotifene, Zaditor, Zaditen, Ketotiphen), the fumaric acid salt of ketotifen, is a second-generation and noncompetitive H1-antihistamine and mast cell stabilizer used to treat allergic symptoms and to prevent asthma attacks.

References: Enkirch T, et al. Identification and in vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs With Broad Anti-influenza A Activity. Front Immunol. 2019 Jun 5;10:1097.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	425.5
Molecular Formula	C19H19NOS.C4H4O4
CAS No.	34580-14-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 8 mg/mL (18.8 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	HC-20511 fumarate; HC 20511 fumarate; Ketotifen, HC20511 fumarate; Ketotifene, Zaditor, Zaditen, Ketotiphen

Protocol	In Vitro	Ketotifen (0-50 μM; 24 h) has inhibitory activity against PR8, pH1N1 and H3N2 with EC50s of 5.9 μM, 33.7 μM and 48.5 μM, respectively; and exhibits relatively low cytotoxicity in MDCK cells (EC50=291 μM)
	In Vivo	Ketotifen (80 mg/kg; i.g.; daily for 3 days) reduces end organ damage and mortality in mice infected with influenza virus
	Animal model	Female C57BL/6 mice (4-6 weeks; intranasal infection with 1×103 TCID50 of PR8 in 30 μL of DMEM)
	Dosages	80 mg/kg
	Administration	i.g.; daily for 3 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3502 mL	11.7509 mL	23.5018 mL	47.0035 mL
5mM	0.4700 mL	2.3502 mL	4.7004 mL	9.4007 mL
10mM	0.2350 mL	1.1751 mL	2.3502 mL	4.7004 mL
20mM	0.1175 mL	0.5875 mL	1.1751 mL	2.3502 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.