Buclizine HCl (UCB-4445)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$400	Check With Us
2g	$650	Check With Us
5g	$1000	Check With Us

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Cat #: V1226 CAS #: 129-74-8 Purity ≥ 98%

Description: Buclizine hydrochloride (AH-2526, UCB 4445; AH2526;UCB-4445, Buclina, Longifene, Posdel, Vibazine), the hydrochloride salt of buclizine which is used for motion sickness, is a piperazine derivative and a sedating antihistamine with antimuscarinic and moderate sedative action.

References: Ean-Jeong Seo, et al. Interaction of antihistaminic drugs with human translationally controlled tumor protein (TCTP) as novel approach for differentiation therapy. Oncotarget. 2016 Mar 29;7(13):16818-39.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	505.95
Molecular Formula	C28H33ClN2.2HCl
CAS No.	129-74-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: <1 mg/mLr
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	Chemical Name: 1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride InChi Key: SDBHDSZKNVDKNU-UHFFFAOYSA-N InChi Code: InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H SMILES Code: ClC1=CC=C(C(N2CCN(CC3=CC=C(C(C)(C)C)C=C3)CC2)C4=CC=CC=C4)C=C1.[H]Cl.[H]Cl
Synonyms	UCB-4445; AH 2526, UCB4445; AH-2526, UCB 4445; AH2526; Buclizine; Buclizine dihydrochloride; AH-2526, UCB 4445; AH2526;UCB-4445, Buclina, Longifene, Posdel, Vibazine.

Protocol	In Vivo	Buclizine dihydrochloride (30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation) shows potent teratogens in the rat
	Animal model	Eighty-seven mature female rats weighing 240±20 grams
	Dosages	30, 40, 60, 100, and 200 mg/kg
	Administration	30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9765 mL	9.8824 mL	19.7648 mL	39.5296 mL
5mM	0.3953 mL	1.9765 mL	3.9530 mL	7.9059 mL
10mM	0.1976 mL	0.9882 mL	1.9765 mL	3.9530 mL
20mM	0.0988 mL	0.4941 mL	0.9882 mL	1.9765 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.