Cetirizine DiHCl (P071)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
10g	$250	Check With Us
25g	$450	Check With Us
50g	$675	Check With Us

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Cat #: V1218 CAS #: 83881-52-1 Purity ≥ 98%

Description: Cetirizine 2HCl (P-071; UCB P071; Reactine; Zyrtec; Alerlisin; AC-170; P071), the dihydrochloride salt of cetirizine and a major active metabolite of hydroxyzine, is a 2nd-generation antihistamine used in the treatment of allergies, hay fever, angioedema, and urticarial etc.

References: Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	461.81
Molecular Formula	C21H25ClN2O3.2HCl
CAS No.	83881-52-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 92 mg/mL (199.2 mM)r
	Water: 92 mg/mL (199.2 mM)r
	Ethanol: <1 mg/mL
Solubility In Vivo	Chemical Name: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride InChi Key: PGLIUCLTXOYQMV-UHFFFAOYSA-N InChi Code: InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H SMILES Code: C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
Synonyms	UCB-P071; P071; Reactine; Zyrtec; Alerlisin; UCBP071; P-071; Cetirizine Hydrochloride; P 071; UCB P071; Cetirizine Dihydrochloride

Protocol	In Vivo	Cetirizine (20 mg/kg, mice, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen
Protocol	Dosages	2 or 20 mg/kg

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1654 mL	10.8270 mL	21.6539 mL	43.3079 mL
5mM	0.4331 mL	2.1654 mL	4.3308 mL	8.6616 mL
10mM	0.2165 mL	1.0827 mL	2.1654 mL	4.3308 mL
20mM	0.1083 mL	0.5413 mL	1.0827 mL	2.1654 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.