Macitentan n-butyl analogue

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1050	Check With Us
200mg	$1575	Check With Us
500mg	$2400	Check With Us

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Cat #: V30150 CAS #: 556797-16-1 Purity ≥ 99%

Description: Macitentan n-butyl analogue, an n-butyl derivative of Macitentan, is an ETA/ETB endothelin (ET) receptor dual antagonist that has potential usefulness in the treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

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Molecular Weight (MW)	587.28
Molecular Formula	C20H21Br2N5O4S
CAS No.	556797-16-1

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7028 mL	8.5138 mL	17.0277 mL	34.0553 mL
5mM	0.3406 mL	1.7028 mL	3.4055 mL	6.8111 mL
10mM	0.1703 mL	0.8514 mL	1.7028 mL	3.4055 mL
20mM	0.0851 mL	0.4257 mL	0.8514 mL	1.7028 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.