Siponimod (BAF312)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $880 | Check With Us |
| 500mg | $1500 | Check With Us |
| 1g | $2250 | Check With Us |
: Cat #: V1505 CAS #: 1230487-00-9 Purity ≥ 98%
Description: Siponimod (BAF-312; WHO-9491; NVP-BAF-312; Mayzent) is a novel, potent and orally bioavailable S1P receptor modulator with immunomodulating activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 516.6 |
|---|---|
| Molecular Formula | C29H35F3N2O3 |
| CAS No. | 1230487-00-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (193.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 44 mg/mL (85.2 mM) | |
| Synonyms | BAF-312; WHO 9491; NVP-BAF-312; BAF 312; WHO-9491; NVP-BAF312; BAF312; NVP-BAF312-NX; WHO9491; NVP-BAF 312; NVP-BAF312-AEA; Siponimod; Mayzent. |
| Protocol | In Vitro | Siponimod (compound 32) exhibits selectivity to S1P1 and S1P5, and spares activity on the S1P2, S1P3 and S1P4 receptors |
|---|---|---|
| In Vivo | Siponimod (1 g/kg; i.v.; single dose) shows low to moderate in monkey, but high in rat in metabolism studies with liver microsomes. The absolute bioavailability is 50 and 71% in the rat and monkey, respectively, indicating no major presystemic first pass metabolism |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9357 mL | 9.6787 mL | 19.3573 mL | 38.7147 mL |
| 5mM | 0.3871 mL | 1.9357 mL | 3.8715 mL | 7.7429 mL |
| 10mM | 0.1936 mL | 0.9679 mL | 1.9357 mL | 3.8715 mL |
| 20mM | 0.0968 mL | 0.4839 mL | 0.9679 mL | 1.9357 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.