Opaganib (ABC294640)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1350	Check With Us
500mg	$1950	Check With Us
1g	$2925	Check With Us

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Cat #: V1506 CAS #: 915385-81-8 Purity ≥ 98%

Description: Opaganib (formerly known as ABC294640; ABC-294640; Trade name Yeliva) is a novel, potent, selective, competitive and orally bioavailable aryladamantane analog and selective sphingosine kinase-2 (SphK2) inhibitor with potential anticancer activity.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	380.91
Molecular Formula	C23H25ClN2O
CAS No.	915385-81-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 76 mg/mL (199.5 mM)r
	Water: <1 mg/mLr
	Ethanol: 28 mg/mL (73.5 mM)
Synonyms	ABC-294640; Trade name Yeliva; ABC294640; ABC 294640

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6253 mL	13.1265 mL	26.2529 mL	52.5058 mL
5mM	0.5251 mL	2.6253 mL	5.2506 mL	10.5012 mL
10mM	0.2625 mL	1.3126 mL	2.6253 mL	5.2506 mL
20mM	0.1313 mL	0.6563 mL	1.3126 mL	2.6253 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.