JTE-013 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $500 | Check With Us |
| 250mg | $900 | Check With Us |
| 500mg | $1350 | Check With Us |
: Cat #: V23005 CAS #: 383150-41-2 (free base) Purity ≥ 99%
Description: JTE-013 HCl is a novelm potent, selective antagonist of sphingosine-1-phosphate 2 (S1P2) receptor, with IC50 of 17 and 22 nM, respectively, (IC50 >10 µM for for binding to human S1P1 and S1P3).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 408.29 |
|---|---|
| Molecular Formula | C17H19Cl2N7O |
| CAS No. | 383150-41-2 (free base) |
| Protocol | In Vitro | JTE-013 (10-1000 nM; 30 mins) reverses S1P-induced Akt inhibition and inhibits S1P-induced ERK activation |
|---|---|---|
| In Vivo | JTE-013 (gavage; 30 mg/kg daily for 14 consecutive days) reduces tumor size and tumor weight | |
| Animal model | Six-week-old female athymic NCr-nu/nu nude mice | |
| Dosages | 30 mg/kg | |
| Administration | Gavage; daily for 14 consecutive days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4492 mL | 12.2462 mL | 24.4924 mL | 48.9848 mL |
| 5mM | 0.4898 mL | 2.4492 mL | 4.8985 mL | 9.7970 mL |
| 10mM | 0.2449 mL | 1.2246 mL | 2.4492 mL | 4.8985 mL |
| 20mM | 0.1225 mL | 0.6123 mL | 1.2246 mL | 2.4492 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.