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Phloretin

This product is for research use only, not for human use. We do not sell to patients.

Phloretin
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
2g$180To Be Confirmed.
5g$299To Be Confirmed.
10g$445To Be Confirmed.
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Cat #: V4942 CAS #: 60-82-2 Purity ≥ 98%

Description: Phloretin (also known as NSC 407292 and RJC 02792), a naturally occuring dihydrochalcone flavonoid mainly found in fruit, leaves, and roots of apple tree, inhibits a variety of transporters such as the monocarboxylate transporters MCT1 and MCT2 (IC50 = 28 and 14 µM, respectively).

References: Huang WC, et al. Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures. Mol Nutr Food Res. 2013 Oct;57(10):1803-13.

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CAS No.60-82-2
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
ProtocolIn Vitro(0-100 μM； 24 hours) has an effect on transcription factors of adipogenesis in differentiated 3T3-L1 adipocytes, reducing PPAR-γ, C/EBPα, and C/EBPβ in a dose-dependent manner
In VivoPhloretin (oral administration; 50 or 100 mg/kg; Once a day) Reduces oxidative stress and malondialdehyde (MDA) and hydrogen peroxide (H) in paw tissues2Or2), which reduces the productivity of anti-collagen antibodies in the serum
Animal modelCollagen-Induced Arthritis (CIA) Mice
Dosages50 or 100 mg/kg
AdministrationOral adminstration
These protocols are for reference only. InvivoChem does not independently validate these methods.
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.