Ki16425 (Debio 0719)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$750	Check With Us
500mg	$1150	Check With Us
1g	$1725	Check With Us

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Cat #: V1496 CAS #: 355025-24-0 Purity ≥ 98%

Description: Ki16425 (also called Ki 16425; Debio-0719; Ki-16425; Debio 0719) is a competitive, selective and reversible antagonist of LPA which inhibits LPA1, LPA2 and LPA3 with Ki values of 0.34 μM, 6.5 μM and 0.93 μM in RH7777 cell lines, respectively.

References: Ma L, et al. Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist. J Neurochem, 2009, 109(2), 603-610.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	474.96
Molecular Formula	C23H23ClN2O5S
CAS No.	355025-24-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 94 mg/mL (197.9 mM)r
	Water: <1 mg/mLr
	Ethanol: 94 mg/mL (197.9 mM)
Solubility In Vivo	5% DMSO+95% Corn oil: 30 mg/mL
Synonyms	Ki16425; Debio0719; Ki-16425; Debio 0719; Ki 16425; Debio-0719

Protocol	In Vivo	Ki16425 (Debio 0719) (1-30 mg/kg; i.p.; at 30 min prior to LPA injection) inhibits LPA-induced neuropathic pain-like behaviors
	Animal model	20-24 g male standard ddY-strain mice
	Dosages	1-30 mg/kg
	Administration	Intraperitoneal injection; at 30 minutes prior to LPA injection

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1054 mL	10.5272 mL	21.0544 mL	42.1088 mL
5mM	0.4211 mL	2.1054 mL	4.2109 mL	8.4218 mL
10mM	0.2105 mL	1.0527 mL	2.1054 mL	4.2109 mL
20mM	0.1053 mL	0.5264 mL	1.0527 mL	2.1054 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.