Ki16198
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1400 | Check With Us |
| 500mg | $2020 | Check With Us |
| 1g | $3030 | Check With Us |
: Cat #: V1497 CAS #: 355025-13-7 Purity ≥ 98%
Description: Ki16198 (Ki 16198; Ki-16198), the methyl ester of Ki16425, is a potent LPA (Lysophosphatidic acid) receptor antagonist with important biological activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 488.98 |
|---|---|
| Molecular Formula | C24H25ClN2O5S |
| CAS No. | 355025-13-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 96 mg/mL (196.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 35 mg/mL (71.6 mM) | |
| Solubility In Vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL |
| Synonyms | Ki16198; Ki-16198; Ki 16198; |
| Protocol | In Vitro | Ki16198 (0-10 μM; 48 hours) is effective to inhibit migration and invasion responses to LPA with a potency similar to that of Ki16425. The inhibitory effects Ki16198 on the invasion response to LPA, but not to EGF in several pancreatic cancer cell lines, including Panc-1,CFPAC-1, and BxPC-3 cells |
|---|---|---|
| In Vivo | Ki16198 (oral administaion; 1 mg in 500 ul; 28 days) significantly decreases the degree of metastasis activity in Ki16198-treated mice. Similiar to liver, metastasis to lung and brain in mice is also observed | |
| Animal model | Male BALB/c nude mice (6 weeks old) | |
| Dosages | 1 mg in 500 ul | |
| Administration | Oral administaion; 28 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0451 mL | 10.2254 mL | 20.4507 mL | 40.9015 mL |
| 5mM | 0.4090 mL | 2.0451 mL | 4.0901 mL | 8.1803 mL |
| 10mM | 0.2045 mL | 1.0225 mL | 2.0451 mL | 4.0901 mL |
| 20mM | 0.1023 mL | 0.5113 mL | 1.0225 mL | 2.0451 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.