Mozavaptan (OPC-31260)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $480 | Check With Us |
| 500mg | $945 | Check With Us |
| 1g | $1415 | Check With Us |
: Cat #: V1486 CAS #: 137975-06-5 Purity ≥ 98%
Description: Mozavaptan (formerly known as OPC-31260; OPC-31260l; OPC31260; OPC31260l) is an orally bioactive, selective and competitive vasopressin receptor antagonist for both V1 and V2 receptors with anti-hypernatremic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 427.54 |
|---|---|
| Molecular Formula | C27H29N3O2 |
| CAS No. | 137975-06-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 1 mg/mL (2.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 1 mg/mL (2.3 mM) | |
| Solubility In Vivo | 30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL |
| Synonyms | OPC-31260; OPC31260l; OPC31260; OPC 31260l; OPC 31260; OPC-31260l; OPC31260 l; OPC-31260-l; OPC 31260 l |
| Protocol | In Vitro | Mozavaptan (OPC-31260) inhibits AVP binding to binding to rat liver (V1 receptor) and kidney (V2 receptor) plasma membranes in a competitive manner and that it is about 100 times more selective for V2 receptors. Kd value for [3H]-AVP in rat liver is 1.1 nM; in rat kidney is 1.38 nM. The Kd of [3H]-AVP is reduced significantly in both rat liver and kidney in the presence of Mozavaptan (Kd of 2.47 nM and 5.51 nM for V1 receptor at the doses of 0.3 μM and 1 μM.respectively; Kd of 2.4 nM and 4.03 nM for V2 receptor at the doses of 0.3 μM and 1 μM.respectively) |
|---|---|---|
| In Vivo | Mozavaptan (OPC-31260; 1-30 mg/kg; oral administration; hydrated conscious rats) treatment dose-dependently increases urine flow and decreased urine osmolality | |
| Animal model | Hydrated conscious rats (300-350 g) | |
| Dosages | 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg | |
| Administration | Oral administration |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3390 mL | 11.6948 mL | 23.3896 mL | 46.7792 mL |
| 5mM | 0.4678 mL | 2.3390 mL | 4.6779 mL | 9.3558 mL |
| 10mM | 0.2339 mL | 1.1695 mL | 2.3390 mL | 4.6779 mL |
| 20mM | 0.1169 mL | 0.5847 mL | 1.1695 mL | 2.3390 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.