Preladenant (MK-3814; SCH420814)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $850 | Check With Us |
| 500mg | $1350 | Check With Us |
| 1g | $2025 | Check With Us |
: Cat #: V3944 CAS #: 377727-87-2 Purity ≥ 98%
Description: Preladenant (formerly known as MK-3814; SCH-420814) is a novel potent, selective and competitive antagonist of adenosine A2A receptor with potential immunomodulatory effects and may be used for the treatment for Parkinson's disease.
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| Molecular Weight (MW) | 503.57 |
|---|---|
| Molecular Formula | C25H29N9O3 |
| CAS No. | 377727-87-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | NC1=NC(N(CCN2CCN(C3=CC=C(OCCOC)C=C3)CC2)N=C4)=C4C5=NC(C6=CC=CO6)=NN15 |
| Synonyms | SCH420814; MK 3814; SCH-420814; MK-3814; SCH 420814; MK3814 |
| Protocol | In Vitro | Preladenant also completely antagonizes cAMP in cells expressing the recombinant human A2A receptor. Preladenant is determined to has KB values of 1.3 nM at the A2A receptor; the value is in good agreement with the Ki value determined in the radioligand binding assay. A similar functional assay with A2B receptor-expressing cells is used to demonstrate selectivity over A2B receptors. In this assay, the KB value for Preladenant is 1.2 μM, indicating that Preladenant is 923-fold selective for the A2A receptor over the A2B receptor |
|---|---|---|
| In Vivo | Preladenant (1 mg/kg) inhibits L-Dopa-induced behavioral sensitization after repeated daily administration, which suggests a reduced risk of the development of dyskinesias. Preladenant exhibits antidepressant-like profiles in models of behavioral despair, namely the mouse tail suspension test and the mouse and rat forced swim test |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9858 mL | 9.9291 mL | 19.8582 mL | 39.7164 mL |
| 5mM | 0.3972 mL | 1.9858 mL | 3.9716 mL | 7.9433 mL |
| 10mM | 0.1986 mL | 0.9929 mL | 1.9858 mL | 3.9716 mL |
| 20mM | 0.0993 mL | 0.4965 mL | 0.9929 mL | 1.9858 mL |
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Step Two: Enter the in vivo formulation
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Method for preparing in vivo formulation:
Take
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DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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