Nicergoline
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $450 | Check With Us |
| 1g | $650 | Check With Us |
| 5g | $1755 | Check With Us |
: Cat #: V11965 CAS #: 27848-84-6 Purity ≥ 99%
Description: Nicergoline tartrate is a naturally occuring ergot derivative and a vasoactive drug with α-adrenergic blocking activity, producing vasodilatation.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 484.39 |
|---|---|
| Molecular Formula | C24H26BrN3O3 |
| CAS No. | 27848-84-6 |
| Protocol | In Vivo | Nicergoline (10 mg/kg; i.v. once daily for 60 d) inhibits apoptosis, inflammation and oxidative stress in hippocampal cells, and regulates the activity of hippocampal cells through the PI3K/AKT signaling pathway in mice |
|---|---|---|
| Animal model | 3×Tg-AD mice (male, 28-35 g, 6 weeks) with the Alzheimer's disease | |
| Dosages | 10 mg/kg | |
| Administration | I.v. once daily for 60 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0645 mL | 10.3223 mL | 20.6445 mL | 41.2890 mL |
| 5mM | 0.4129 mL | 2.0645 mL | 4.1289 mL | 8.2578 mL |
| 10mM | 0.2064 mL | 1.0322 mL | 2.0645 mL | 4.1289 mL |
| 20mM | 0.1032 mL | 0.5161 mL | 1.0322 mL | 2.0645 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.