ML241 HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
Size | Price | Stock |
---|---|---|
250mg | $850 | Check With Us |
500mg | $1450 | Check With Us |
1g | $2175 | Check With Us |
Cat #: V4006 CAS #: 2070015-13-1 Purity ≥ 98%
Description: ML241 HCl is a novel and potent p97 inhibitor which inhibits p97 ATPase with an IC50 value of 100 nM.
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Molecular Weight (MW) | 408.93 |
---|---|
Molecular Formula | C23H25ClN4O |
CAS No. | 2070015-13-1 |
Storage | -20℃ for 3 years in powder formr |
-80℃ for 2 years in solvent | |
Solubility In Vitro | DMSO: ≥ 30mg/mLr |
Water: N/Ar | |
Ethanol: N/A | |
SMILES Code | Cl[H].C1(N2C3=CC=CC=C3OCC2)=NC(NCC4=CC=CC=C4)=C5CCCCC5=N1 |
Synonyms | ML241 HCl; ML-241; ML 241 hydrochloride |
Protocol | In Vitro | ML241 hydrochloride is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 values of 100 nM. ML241 inhibits p97 competitively with respect to ATP with a Ki values of 0.35 μM. ML241 (20 μM) shows no obvious inhibition of the appr 170 kinases tested. ML241 stabilizes UbG76V-GFP with IC50 of 3.5 μM |
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These protocols are for reference only. InvivoChem does not
independently validate these methods.
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 2.4454 mL | 12.2270 mL | 24.4541 mL | 48.9081 mL |
5mM | 0.4891 mL | 2.4454 mL | 4.8908 mL | 9.7816 mL |
10mM | 0.2445 mL | 1.2227 mL | 2.4454 mL | 4.8908 mL |
20mM | 0.1223 mL | 0.6114 mL | 1.2227 mL | 2.4454 mL |
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.