Palifosfamide (ZIO-201)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1550 | Check With Us |
| 250mg | $2850 | Check With Us |
| 500mg | $4275 | Check With Us |
: Cat #: V4078 CAS #: 31645-39-3 Purity ≥ 98%
Description: Palifosfamide (also known as Isophosphoramide mustard; IPM; ZIO201), a synthetic mustard compound and the active metabolite of ifosfamide, is a novel DNA alkylator with antitumor activity.
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| Molecular Weight (MW) | 221.02 |
|---|---|
| Molecular Formula | C₄H₁₁Cl₂N₂O₂P |
| CAS No. | 31645-39-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 40 mg/mLr |
| Water: 12 mg/mLr | |
| Ethanol: N/A | |
| SMILES Code | O=P(NCCCl)(NCCCl)O |
| Synonyms | NSC 297900; NSC-297900; NSC297900; ZIO201; ZIO-201; ZIO 201; IPAM; isophosphoramide mustard |
| Protocol | In Vitro | Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 ro 6.75 μM for most cell lines except OS222 (IC50=31.5 μM) |
|---|---|---|
| In Vivo | Tumor growth inhibition is seen in both OS31 and OS33 xenografts and the RMS xenograft resulting in a significant difference in event-free survival between the control and the treated groups. Differential gene expression of ALDH3A1 but not ALDH1A1 is noted in the OS31 xenograft |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.5245 mL | 22.6224 mL | 45.2448 mL | 90.4895 mL |
| 5mM | 0.9049 mL | 4.5245 mL | 9.0490 mL | 18.0979 mL |
| 10mM | 0.4524 mL | 2.2622 mL | 4.5245 mL | 9.0490 mL |
| 20mM | 0.2262 mL | 1.1311 mL | 2.2622 mL | 4.5245 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.