Iniparib (SAR240550; BSI201; NSC746045; IND71677)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $550 | Check With Us |
| 500mg | $900 | Check With Us |
| 1g | $1350 | Check With Us |
: Cat #: V0303 CAS #: 160003-66-7 Purity ≥ 98%
Description: Iniparib (SAR-240550; BSI-201; NSC-746045; IND-71677) is a novel, potent, and irreversible inhibitor of PARP1 [poly(ADP-ribose) polymerase-1] with potential anticancer activity.
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- Related Biological Data
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| Molecular Weight (MW) | 292.03 |
|---|---|
| Molecular Formula | C7H5IN2O3 |
| CAS No. | 160003-66-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 58 mg/mL (198.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 28 mg/mL (95.9 mM) | |
| Synonyms | NSC-746045, IND-71677; BSI-201; BSI201; BSI 201; NSC746045; NSC-746045; NSC 746045; ND-71677; NIBA; INO-2BA; SAR-240550; SAR 240550; SAR240550; IND-71677; IND 71677; IND71677; Iniparib; |
| Protocol | In Vitro | Iniparib nonselectively modifies cysteine-containing proteins in tumor cells. Iniparib (100 μM) weakly inhibits SSB repair, and the inhibition can be reversed by knockdown of PARP1. Iniparib in combination with cisplatin is cytotoxic to Myc/MDA-231 with EMT changes |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4243 mL | 17.1215 mL | 34.2431 mL | 68.4861 mL |
| 5mM | 0.6849 mL | 3.4243 mL | 6.8486 mL | 13.6972 mL |
| 10mM | 0.3424 mL | 1.7122 mL | 3.4243 mL | 6.8486 mL |
| 20mM | 0.1712 mL | 0.8561 mL | 1.7122 mL | 3.4243 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.