AZD5305
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1950 | 3-6 Days |
| 250mg | $3250 | 3-6 Days |
| 500mg | $4875 |
: Cat #: V2472 CAS #: 2589531-76-8 Purity ≥ 99%
Description: AZD-5305 (AZD5305) is a novel, potent, selective and orally bioactive PARP [Poly(ADP-ribose)polymerase-1] inhibitor with anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 406.48 |
|---|---|
| Molecular Formula | C22H26N6O2 |
| CAS No. | 2589531-76-8 |
| Protocol | In Vitro | Saruparib (AZD5305) (0.1 nM-100 μM) inhibits PARylation in A549 WT cells by selectively blocking PARP1 enzyme activity with an IC50 of 2.3 nM |
|---|---|---|
| In Vivo | Saruparib (AZD5305) (0.01-0.3 mg/kg; p.o.; daily, for 35 days; Female Han Wistar rats) show sustained antitumor activity in in vivo BRCAm xenografts and PDX models | |
| Animal model | Female Han Wistar rats with BRCAm xenograft and PDX models (12-13 weeks of age) | |
| Dosages | 0.01, 0.03, 0.1, and 0.3 mg/kg | |
| Administration | Oral administration; daily, for 35 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4601 mL | 12.3007 mL | 24.6015 mL | 49.2029 mL |
| 5mM | 0.4920 mL | 2.4601 mL | 4.9203 mL | 9.8406 mL |
| 10mM | 0.2460 mL | 1.2301 mL | 2.4601 mL | 4.9203 mL |
| 20mM | 0.1230 mL | 0.6150 mL | 1.2301 mL | 2.4601 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.