HDAC-IN-4 (CXD-101; AZD-9468)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $650 | Check With Us |
| 250mg | $1200 | Check With Us |
| 500mg | $1800 | Check With Us |
: Cat #: V2869 CAS #: 934828-12-3 Purity ≥ 98%
Description: HDAC-IN-4 (also known as CXD101, AZD9468) is a novel and potent inhibitor of histone deacetylase (HDAC) with potential anticancer and immunomodulatory activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 403.52 |
|---|---|
| Molecular Formula | C24H29N5O |
| CAS No. | 934828-12-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 31 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: | |
| SMILES Code | O=C(NC1=CC=CC=C1N)C2=CC=C(C3CCN(CC4=CN(C)N=C4C)CC3)C=C2 |
| Synonyms | CXD-101; AZD 9468; CXD101; AZD-9468; CXD 101; HDAC-IN-4; AZD9468 |
| Protocol | In Vitro | Zabadinostat has been tested in vitro in colon, lung, non-Hodgkin lymphoma, and myeloma cell lines with IC50s ranged from 0.2 to 15 μM |
|---|---|---|
| In Vivo | Zabadinostat substantially reduces tumor size in murine xenograft lung (A549a) and colon (HT29) models at a dose of 50 mg/kg. Tumor reductions are found to be associated with increased histone acetylation and decreased HDAC enzyme activity |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4782 mL | 12.3910 mL | 24.7819 mL | 49.5638 mL |
| 5mM | 0.4956 mL | 2.4782 mL | 4.9564 mL | 9.9128 mL |
| 10mM | 0.2478 mL | 1.2391 mL | 2.4782 mL | 4.9564 mL |
| 20mM | 0.1239 mL | 0.6195 mL | 1.2391 mL | 2.4782 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.