BRD73954
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1150 | Check With Us |
| 1g | $1725 | Check With Us |
: Cat #: V0263 CAS #: 1440209-96-0 Purity ≥ 98%
Description: BRD73954 (BRD-73954) is a novel, potent and dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 284.31 |
|---|---|
| Molecular Formula | C16H16N2O3 |
| CAS No. | 1440209-96-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 56 mg/mL (197.0 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 2 mg/mL warmed (9.3 mM) | |
| Solubility In Vivo | O=C(C1=CC=CC(C(NO)=O)=C1)NCCC2=CC=CC=C2 |
| Synonyms | BRD-73954; BRD73954; BRD 73954 Chemical Name: N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide InChi Key: FIHKWEQJEDRIFS-UHFFFAOYSA-N InChi Code: InChI=1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20) SMILES Code: O=C(C1=CC=CC(C(NO)=O)=C1)NCCC2=CC=CC=C2 |
| Protocol | In Vitro | BRD73954 (10 µM; 48 h; HeLa cells) inhibits HDAC6 activity via upregulation of Ac-Tubulin |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5173 mL | 17.5864 mL | 35.1729 mL | 70.3457 mL |
| 5mM | 0.7035 mL | 3.5173 mL | 7.0346 mL | 14.0691 mL |
| 10mM | 0.3517 mL | 1.7586 mL | 3.5173 mL | 7.0346 mL |
| 20mM | 0.1759 mL | 0.8793 mL | 1.7586 mL | 3.5173 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.