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Nimustine HCl (ACNU)

This product is for research use only, not for human use. We do not sell to patients.

Nimustine HCl (ACNU)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$350Check With Us
2g$450Check With Us
5g$680Check With Us
email: [email protected]        [email protected]

Cat #: V5089 CAS #: 55661-38-6 Purity ≥ 98%

Description: Nimustine hydrochloride (also known as ACNU), an approved chemotherapeutic drug, is a potent DNA cross-linking and DNA alkylating agent for cancer treatment, it induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for especially glioblastomas / malignant brain tumors.

References: Tomicic MT, et al. Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. Oncotarget. 2015 Oct 20;6(32):33755-68.

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Molecular Weight (MW)309.15
Molecular FormulaC9H14Cl2N6O2
CAS No.55661-38-6
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.2347 mL16.1734 mL32.3468 mL64.6935 mL
5mM0.6469 mL3.2347 mL6.4694 mL12.9387 mL
10mM0.3235 mL1.6173 mL3.2347 mL6.4694 mL
20mM0.1617 mL0.8087 mL1.6173 mL3.2347 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.