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Remdesivir O-desphosphate acetonide impurity

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Remdesivir O-desphosphate acetonide impurity
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$450Check With Us
1g$750Check With Us
5g$2030Check With Us

Cat #: V2203 CAS #: 1191237-80-5 Purity ≥ 98%

Description: Remdesivir O-desphosphate acetonide impurity is a Remdesivir impurity and an important intermediate to synthesize antiviral drug remdesivir.

References: Dustin Siegel, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661.

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Molecular Weight (MW)331.33
Molecular FormulaC15H17N5O4
CAS No.1191237-80-5
ProtocolIn VitroRemdesivir O-desphosphate acetonide impurity (analogue 21) is a 2′,3′-acetonide protected analogue of Remdesivir
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0181 mL15.0907 mL30.1814 mL60.3628 mL
5mM0.6036 mL3.0181 mL6.0363 mL12.0726 mL
10mM0.3018 mL1.5091 mL3.0181 mL6.0363 mL
20mM0.1509 mL0.7545 mL1.5091 mL3.0181 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.