CRT0044876
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 1g | $450 | Check With Us |
| 2g | $650 | Check With Us |
| 5g | $980 | Check With Us |
: Cat #: V1440 CAS #: 6960-45-8 Purity ≥ 98%
Description: CRT0044876 (CRT-0044876; NSC 69877, 7-NO2-ICA; NSC-69877; CRT 0044876; NSC69877), an indole analog, is a potent and selective APE1 inhibitor with potential antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
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| Molecular Weight (MW) | 206.15 |
|---|---|
| Molecular Formula | C9H6N2O4 |
| CAS No. | 6960-45-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 41 mg/mL (198.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | Chemical Name: 7-Nitro-1H-indole-2-carboxylic acid. InChi Key: BIUCOFQROHIAEO-UHFFFAOYSA-N InChi Code: InChI=1S/C9H6N2O4/c12-9(13)6-4-5-2-1-3-7(11(14)15)8(5)10-6/h1-4,10H,(H,12,13) SMILES Code: O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)O |
| Synonyms | CRT-0044876; NSC 69877, 7-NO2-ICA; CRT0044876; NSC-69877; CRT 0044876; NSC69877. |
| Protocol | In Vitro | A key step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP endonuclease. CRT0044876 has an IC50 for inhibition of APE1 of ∼3 μM and not only inhibits AP site cleavage catalyzed by purified APE1, but also cleavage directed by APE1 in a HeLa whole cell extract. CRT0044876 inhibits the 3′-phosphoglycolate diesterase activity of APE1 with an IC50 of ∼5 μM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.8508 mL | 24.2542 mL | 48.5084 mL | 97.0167 mL |
| 5mM | 0.9702 mL | 4.8508 mL | 9.7017 mL | 19.4033 mL |
| 10mM | 0.4851 mL | 2.4254 mL | 4.8508 mL | 9.7017 mL |
| 20mM | 0.2425 mL | 1.2127 mL | 2.4254 mL | 4.8508 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.