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Tegafur (FT-207; NSC 148958)

This product is for research use only, not for human use. We do not sell to patients.

Tegafur (FT-207; NSC 148958)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5g$245Check With Us
10g$445Check With Us
20g$668Check With Us

Cat #: V1479 CAS #: 17902-23-7 Purity ≥ 98%

Description: Tegafur (formerly known as Fluorafur, FT-207, NSC-148958; Uftoral; UFT), a component of tegafur-uracil, is a chemotherapeutic anticancer prodrug of 5-FU (5-Fluorouracil, an anticancer drug) that is commonly used in the treatment of various cancers.

References: José L. Ariasa, et al. Engineering of an antitumor (core/shell) magnetic nanoformulation based on the chemotherapy agent ftorafur. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2011,384(1-3): 157-163.

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Molecular Weight (MW)200.17
Molecular FormulaC8H9FN2O3
CAS No.17902-23-7
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 40 mg/mL (199.8 mM)r
Water: 8 mg/mL (40 mM)r
Ethanol: 7 mg/mL (35 mM)
Solubility In VivoChemical Name: 5-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione InChi Key: WFWLQNSHRPWKFK-UHFFFAOYSA-N InChi Code: InChI=1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13) SMILES Code: O=C1NC(C(F)=CN1C2OCCC2)=O
SynonymsFluorafur, FT-207, NSC-148958; FT207, NSC148958; FT 207, NSC 148958; Uracil and Ftorafur; Uracil and Tegafur; Trade name: Uftoral; UFT.
ProtocolIn VitroTegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.9958 mL24.9788 mL49.9575 mL99.9151 mL
5mM0.9992 mL4.9958 mL9.9915 mL19.9830 mL
10mM0.4996 mL2.4979 mL4.9958 mL9.9915 mL
20mM0.2498 mL1.2489 mL2.4979 mL4.9958 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.