Irinotecan (CPT-11)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$249	Check With Us
1g	$390	Check With Us
5g	$1170	Check With Us

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Cat #: V1393 CAS #: 97682-44-5 Purity ≥ 98%

Description: Irinotecan (also known as CPT-11; Camptosar; Irinophore C; CPT11; Irinotecan lactone; Irinotecanum), a semisynthetic analog of camptothecin and the prodrug of 7-ethyl-10-hydroxy-camptothecin (SN-38), is a topoisomerase I inhibitor approved for use as an anticancer drug.

References: Morales C, et al. Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor. J Neurooncol. 2002 Feb;56(3):219-26.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	586.68
Molecular Formula	C33H38N4O6
CAS No.	97682-44-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 7 mg/mL (11.9 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Solubility In Vivo	30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
Synonyms	CPT-11; (+)-Irinotecan; Camptosar; Irinophore C; CPT 11; CPT11; Irinotecan; Irinotecan lactone; Irinotecanum

Protocol	In Vivo	Irinotecan (CPT-11, 5 mg/kg) significantly inhibits the growth of tumors by intratumoral injection daily for 5 days, on two consecutive weeks in rats, and such effects also occur via continuous intraperitoneal infusion by osmotic minipump into mice. However, Irinotecan (10 mg/kg) shows no effect on the growth of tumor by i.p

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7045 mL	8.5225 mL	17.0451 mL	34.0901 mL
5mM	0.3409 mL	1.7045 mL	3.4090 mL	6.8180 mL
10mM	0.1705 mL	0.8523 mL	1.7045 mL	3.4090 mL
20mM	0.0852 mL	0.4261 mL	0.8523 mL	1.7045 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.