Ofloxacin (Hoe-280; DL8280)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50g	$480	Check With Us
100g	$800	Check With Us
200mg	$1200	Check With Us

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Cat #: V1418 CAS #: 82419-36-1 Purity ≥ 98%

Description: Ofloxacin (Hoe-280; DL8280; DL-8280, DR-3355, Hoe280, ORF-28489, Ru-43280) is a synthetic, orally bioavailable and broad-spectrum antibiotic of the fluorinated quinolone class used for the treatment of a variety of bacterial infections such as pneumonia, cellulitis, UTIs-urinary tract infections, prostatitis, and plague.

References: Todd PA, et al. Ofloxacin. A reappraisal of its antimicrobial activity, pharmacology and therapeutic use. Drugs. 1991 Nov;42(5):825-76.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	361.37
Molecular Formula	C18H20FN3O4
CAS No.	82419-36-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 4 mg/mLr
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	DL-8280, DR-3355, Hoe-280, ORF-28489, Ru-43280, DL8280, DR3355, Hoe280, ORF28489, Ru43280, DL 8280, DR 3355, Hoe 280, ORF 28489, Ru 43280

Protocol	In Vitro	Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. In vitro it has a broad spectrum of activity against aerobic Gram-negative and Gram-positive bacteria, although it is poorly active against anaerobes

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7672 mL	13.8362 mL	27.6725 mL	55.3449 mL
5mM	0.5534 mL	2.7672 mL	5.5345 mL	11.0690 mL
10mM	0.2767 mL	1.3836 mL	2.7672 mL	5.5345 mL
20mM	0.1384 mL	0.6918 mL	1.3836 mL	2.7672 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.