Doxorubicin HCl (adriamycin; NSC 123127)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $350 | In Stock |
| 1g | $550 | In Stock |
| 5g | $1650 | In Stock |
: Cat #: V1389 CAS #: 25316-40-9 Purity ≥ 98%
Description: Doxorubicin HCl (formerly known as Adriamycin; FI 106; Adriblastina; DOXOCELL; Doxolem; NSC-123127 etc.) is an anthracycline antibiotic agent with anticancer activity.
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| Molecular Weight (MW) | 579.98 |
|---|---|
| Molecular Formula | C27H29NO11.HCl |
| CAS No. | 25316-40-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (172.4 mM)r |
| Water: 10~50 mg/mLr | |
| Dox HCl can be dissolved in water (1. Annals of Biological Research, 2012, 3,4414-4419r | |
| 2. Annal of Oncology 1999, 10, 391-395)r | |
| Ethanol:<1 mg/mL | |
| Synonyms | Adriamycin; Hydroxydaunorubicin hydrochloride; FI106; ADR; Doxo; Dox HCl; FI-106; FI 106; Adriamycin; Adriacin; Adriblastina; Adriblastine; Adrimedac; DOXOCELL; Doxolem; Doxorubin; Farmiblastina; Rubex. |
| Protocol | In Vitro | Doxorubicin hydrochloride (1-8 µM; 24 and 48 hours) decreases the viability of MCF-10F, MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner[4] |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7242 mL | 8.6210 mL | 17.2420 mL | 34.4839 mL |
| 5mM | 0.3448 mL | 1.7242 mL | 3.4484 mL | 6.8968 mL |
| 10mM | 0.1724 mL | 0.8621 mL | 1.7242 mL | 3.4484 mL |
| 20mM | 0.0862 mL | 0.4310 mL | 0.8621 mL | 1.7242 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.