Costunolide (NSC 106404)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$900	Check With Us
500mg	$1450	Check With Us
1g	$2175	Check With Us

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Cat #: V1388 CAS #: 553-21-9 Purity ≥ 98%

Description: Costunolide [also known as (+)-Costunolide, Costus lactone, CCRIS-6754 and NSC-106404] is a naturally occurring sesquiterpene compound with a wide spectrum of biological activities such as anti-inflammatory, anticancer, antidiabetic, antiviral, antimicrobial, antiulcer, antifungal, antioxidant, and anthelmintic properties.

References: Zhangxiao Peng, et al. Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway.Sci Rep. 2017; 7: 41254.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	232.32
Molecular Formula	C15H20O2
CAS No.	553-21-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 47 mg/mL (202.3 mM)r
	Water: <1 mg/mLr
	Ethanol: 1 mg/mL (4.3 mM)
Solubility In Vivo	2% DMSO+Corn oil: 10 mg/mL
Synonyms	Costus lactone; CCRIS 6754; NSC 106404; CCRIS-6754; NSC-106404; CCRIS6754; NSC106404; Costunolide; Costus lactone; (+)-Costunolide.

Protocol	In Vitro	Costunolide regulates c-Myc mediated apoptosis signaling and 14-3-3-mediated signaling pathways in breast cancer cells
	In Vivo	Costunolide (20 mg/kg; i.p; daily; for 30 days) inhibits breast cancer through c-Myc/p53 and AKT/14-3-3 pathway
	Animal model	4 weeks old female BALB/c nude mice, MDA-MB-231 cells xenograft mouse models
	Dosages	20 mg/kg
	Administration	Intraperitoneal injection, daily, for 30 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.3044 mL	21.5220 mL	43.0441 mL	86.0882 mL
5mM	0.8609 mL	4.3044 mL	8.6088 mL	17.2176 mL
10mM	0.4304 mL	2.1522 mL	4.3044 mL	8.6088 mL
20mM	0.2152 mL	1.0761 mL	2.1522 mL	4.3044 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.