TED-347

This product is for research use only, not for human use. We do not sell to patients.

TED-347
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$950To Be Confirmed
200mg$1425To Be Confirmed
500mg$2150To Be Confirmed

Cat #: V38733 CAS #: 2378626-29-8 Purity ≥ 99%

Description: TED-347 (TED347) is a novel, covalent/irreversible, and allosteric YAP-TEAD protein-protein interaction inhibitor with anticancer activity.

References: Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13.

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Promise
Molecular Weight (MW)313.70
Molecular FormulaC15H11ClF3NO
CAS No.2378626-29-8
ProtocolIn VitroTED-347 (0.5-100 μM; 48 hours) inhibits GBM43 cancer cell viability
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.1878 mL15.9388 mL31.8776 mL63.7552 mL
5mM0.6376 mL3.1878 mL6.3755 mL12.7510 mL
10mM0.3188 mL1.5939 mL3.1878 mL6.3755 mL
20mM0.1594 mL0.7969 mL1.5939 mL3.1878 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.