I3MT-3
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $2050 | In Stock |
| 500mg | $3075 | In Stock |
| 1g | $4610 | In Stock |
: Cat #: V41374 CAS #: 459420-09-8 Purity ≥ 98%
Description: I3MT-3 (also known as HMPSNE; EMT inhibitor-1; EMT inhibitor 1) is a novel, selective, potent, and membrane permeable inhibitor of 3MST (3-Mercaptopyruvate sulfurtransferase) with IC50 of 2.7 μM.
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- Related Biological Data
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| Molecular Weight (MW) | 310.37 |
|---|---|
| Molecular Formula | C17H14N2O2S |
| CAS No. | 459420-09-8 |
| Protocol | In Vitro | I3MT-3 (1 μM) is selective for 3MST and shows a high inhibitory activity (80–90%) even at 10 μM in cell lysate of 3MST-overexpressing HEK293 cells. Besides, it is almost inactive towards the other two H2S-producing enzymes even at 100 μM |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2220 mL | 16.1098 mL | 32.2196 mL | 64.4392 mL |
| 5mM | 0.6444 mL | 3.2220 mL | 6.4439 mL | 12.8878 mL |
| 10mM | 0.3222 mL | 1.6110 mL | 3.2220 mL | 6.4439 mL |
| 20mM | 0.1611 mL | 0.8055 mL | 1.6110 mL | 3.2220 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.