IWP-O1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1250 | Check With Us |
| 500mg | $1850 | Check With Us |
| 1g | $2775 | Check With Us |
: Cat #: V4125 CAS #: 2074607-48-8 Purity ≥ 98%
Description: IWP-O1 is a novel and potent porcn (acyltransferase Porcupine) inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 432.49 |
|---|---|
| Molecular Formula | C26H20N6O |
| CAS No. | 2074607-48-8 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ mg/mLrr |
| Water: N/Arr | |
| Ethanol: N/A | |
| SMILES Code | O=C(NC1=NC=C(C2=CC=CC=C2)C=C1)CN3N=NC(C4=CC=NC=C4)=C3C5=CC=CC=C5 |
| Synonyms | IWP-O1; IWPO1; IWP O1 |
| Protocol | In Vitro | IWP-O1 (17) suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM, 2.5 times more active than the investigational drug LGK974 |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3122 mL | 11.5610 mL | 23.1219 mL | 46.2438 mL |
| 5mM | 0.4624 mL | 2.3122 mL | 4.6244 mL | 9.2488 mL |
| 10mM | 0.2312 mL | 1.1561 mL | 2.3122 mL | 4.6244 mL |
| 20mM | 0.1156 mL | 0.5780 mL | 1.1561 mL | 2.3122 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.