TAK-441
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1950 | To Be Confirmed |
| 100mg | $2925 | To Be Confirmed |
| 200mg | $4380 | To Be Confirmed |
: Cat #: V3704 CAS #: 1186231-83-3 Purity ≥ 98%
Description: TAK-441 is a novel, orally bioavailable, potent and selective Hedgehog (Hh) signaling pathway inhibitor with acceptable solubility and pharmacokinetic properties.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 576.56 |
|---|---|
| Molecular Formula | C28H31F3N4O6 |
| CAS No. | 1186231-83-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >10mMr |
| Water:r | |
| Ethanol: | |
| Synonyms | TAK441; TAK441; TAK 441 |
| Protocol | In Vitro | TAK-441 (compound 11d) (0.03–1000 nM, 48 h) has potent activity in the Gli-luc reporter with an IC50 value of 4.4 nM and good solubility |
|---|---|---|
| In Vivo | TAK-441 (compound 11d) (oral; 10 mg/kg, 100 mg/kg) has favorable exposure and good oral absorption in BALB/c-nu/nu mice | |
| Animal model | rats and dogs | |
| Dosages | 1 mg/kg, 10 mg/kg | |
| Administration | iv, 1 mg/kg; po, 10 mg/kg |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.7344 mL | 8.6721 mL | 17.3442 mL | 34.6885 mL |
| 5mM | 0.3469 mL | 1.7344 mL | 3.4688 mL | 6.9377 mL |
| 10mM | 0.1734 mL | 0.8672 mL | 1.7344 mL | 3.4688 mL |
| 20mM | 0.0867 mL | 0.4336 mL | 0.8672 mL | 1.7344 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.