NSC697923
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $650 | To Be Confirmed |
| 500mg | $1050 | To Be Confirmed |
| 1g | $1575 | To Be Confirmed |
: Cat #: V1317 CAS #: 343351-67-7 Purity ≥ 98%
Description: NSC697923 (NSC 697923; NSC-697923) is a potent, cell-permeable and selective inhibitor of the Ub-conjugating enzyme E2 (UBE2) complex Ubc13-Uev1A with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 267.26 |
|---|---|
| Molecular Formula | C11H9NO5S |
| CAS No. | 343351-67-7 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 53 mg/mL (198.3 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=[N+](C1=CC=C(S(=O)(C2=CC=C(C)C=C2)=O)O1)[O-] |
| Synonyms | NSC 697923; NSC-697923; NSC697923 |
| Protocol | In Vitro | NSC697923 (0-5 μM; 24 hours) shows cytotoxic effect on NB cell lines |
|---|---|---|
| In Vivo | NSC697923 (5 mg/kg; i.p.; daily for 10 days) suppresses NB tumor growth in SH-SY5Y and NGP xenografts | |
| Animal model | 5- to 6-week-old female athymic Ncr nude mice (orthotopic mouse model of NB; SH-SY5Y and NGP xenografts) | |
| Dosages | 5 mg/kg | |
| Administration | I.p.; daily for 10 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7417 mL | 18.7084 mL | 37.4167 mL | 74.8335 mL |
| 5mM | 0.7483 mL | 3.7417 mL | 7.4833 mL | 14.9667 mL |
| 10mM | 0.3742 mL | 1.8708 mL | 3.7417 mL | 7.4833 mL |
| 20mM | 0.1871 mL | 0.9354 mL | 1.8708 mL | 3.7417 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.