ELN484228

This product is for research use only, not for human use. We do not sell to patients.

ELN484228
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$600Check With Us
500mg$1050Check With Us
1g$1575Check With Us

Cat #: V3222 CAS #: 312-63-0 Purity ≥ 98%

Description: ELN484228, a phenyl-sulfonamide compound, is a cell-permeable blocker of α-synuclein which is a key protein in Parkinson’s disease.

References: Tóth G, et al. Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PLoS One. 2014 Feb 14;9(2):e87133.

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Product Promise

Promise
Molecular Weight (MW)251.28
Molecular FormulaC12H10FNO2S
CAS No.312-63-0
Storage-20℃ for 3 years in powder formrr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: >10 mMrr
Water:rr
Ethanol:
SMILES CodeO=S(C1=CC=CC=C1)(NC2=CC=C(F)C=C2)=O
SynonymsELN-484228; ELN484228; ELN 484228
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.9796 mL19.8981 mL39.7962 mL79.5925 mL
5mM0.7959 mL3.9796 mL7.9592 mL15.9185 mL
10mM0.3980 mL1.9898 mL3.9796 mL7.9592 mL
20mM0.1990 mL0.9949 mL1.9898 mL3.9796 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.