Tafamidis | CAS 594839-88-0

Tafamidis

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$630	Check With Us
1g	$930	Check With Us
5g	$2800	Check With Us

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Cat #: V4862 CAS #: 594839-88-0 Purity ≥ 98%

Description: Tafamidis (also known as Fx-1006 or PF-06291826; Vyndaqel and Vyndamax), a potent and selective transthyretin (TTR) stabilizer, is a medication approved for use in delaying disease progression in adults with certain forms of transthyretin amyloidosis.

References: Bulawa, C.E., et al., Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A, 2012. 109(24): p. 9629-34.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	308.114
Molecular Formula	C14H7Cl2NO3
CAS No.	594839-88-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=C(C1=CC=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1)O
Synonyms	Fx-1006, PF06291826; Fx1006, PF-06291826; Fx 1006, Fx-1006A; PF 06291826; Tafamidis; Vyndaqel

Protocol	In Vitro	Tafamidis binds selectively and with negative cooperativity (Kds ∼2 nM and ∼200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.2456 mL	16.2278 mL	32.4555 mL	64.9110 mL
5mM	0.6491 mL	3.2456 mL	6.4911 mL	12.9822 mL
10mM	0.3246 mL	1.6228 mL	3.2456 mL	6.4911 mL
20mM	0.1623 mL	0.8114 mL	1.6228 mL	3.2456 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.