Ebselen
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $450 | In Stock |
| 1g | $645 | In Stock |
| 5g | $1930 | In Stock |
: Cat #: V2837 CAS #: 60940-34-3 Purity ≥ 98%
Description: Ebselen (formerly SPI-1005; PZ-51; DR-3305; CCG-39161), is an organoselenium-based small molecule biochemical compound with potential anti-inflammatory, anti-oxidant, and cytoprotective activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 274.18 |
|---|---|
| Molecular Formula | C₁₃H₉NOSe |
| CAS No. | 60940-34-3 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO:10 mMrr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=C1N(C2=CC=CC=C2)[Se]C3=CC=CC=C13 |
| Synonyms | SPI-1005; PZ-51; DR3305; CCG 39161; SPI1005; PZ51; DR 3305; CCG39161; SPI 1005; PZ 51; DR-3305; CCG-39161 |
| Protocol | In Vitro | Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. Ebselen inhibits inositol monophosphatase (IMPase) |
|---|---|---|
| In Vivo | Ebselen (5, 10 mg/kg; IP) decreases 5-HT2 agonist-induced head twitches in a dose-dependent manner | |
| Animal model | 20-25 g 10-12 week old male C57Bl6 mice | |
| Dosages | 5, 10 mg/kg |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6472 mL | 18.2362 mL | 36.4724 mL | 72.9448 mL |
| 5mM | 0.7294 mL | 3.6472 mL | 7.2945 mL | 14.5890 mL |
| 10mM | 0.3647 mL | 1.8236 mL | 3.6472 mL | 7.2945 mL |
| 20mM | 0.1824 mL | 0.9118 mL | 1.8236 mL | 3.6472 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.