Sarcosine | CAS 107-97-1

Sarcosine

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Size	Price	Stock
25g	$180	Check With Us
50g	$240	Check With Us
100g	$360	Check With Us

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Cat #: V2708 CAS #: 107-97-1 Purity ≥ 98%

Description: Sarcosine [also called N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine] is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist. Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist. The viability of the sarcosine-treated cells is significantly reduced. Sarcosine has weak anticonvulsant properties.

References: Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	89.09
Molecular Formula	C3H7NO2
CAS No.	107-97-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: <1 mg/mLr
	Water: 17 mg/mL (190.8 mM)r
	Ethanol: <1 mg/mL
Solubility In Vivo	O=C(O)CNC
Synonyms	N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine; N-Methylaminoacetic acid; Sarcosin

Protocol	In Vivo	Sarcosine (400-800mg/kg; i.p.) significantly raises the threshold for electroconvulsions
	Animal model	Albino Swiss mice weighing (25-30 g)
	Dosages	100 mg/kg, 200 mg/kg, 400 mg/kg, 800 mg/kg
	Administration	Intraperitoneal injection

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	11.2246 mL	56.1230 mL	112.2460 mL	224.4921 mL
5mM	2.2449 mL	11.2246 mL	22.4492 mL	44.8984 mL
10mM	1.1225 mL	5.6123 mL	11.2246 mL	22.4492 mL
20mM	0.5612 mL	2.8062 mL	5.6123 mL	11.2246 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.