Seltorexant | CAS 1293281-49-8

Seltorexant

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$750	Check With Us
500mg	$1250	Check With Us
1g	$1875	Check With Us

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Cat #: V6669 CAS #: 1293281-49-8 Purity ≥ 99%

Description: Seltorexant (also known as MIN-202 and JNJ-42847922), is a novel, potent and selective orexin-2 receptor antagonist. It can promote sleep in various species and is under development for the treatment of insomnia and major depressive disorder.

References: Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82.

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Stock Solution Preparation
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Molecular Weight (MW)	407.4534
Molecular Formula	C21H22FN7O
CAS No.	1293281-49-8
Synonyms	MIN-202; JNJ42847922; MIN 202; JNJ-42847922; MIN202; JNJ 42847922; Seltorexant;

Protocol	In Vivo	Seltorexant (JNJ-42847922) (3-30 mg/kg; p.o.) dose-dependently induces and prolongs sleep in male Sprague-Dawley rats
	Animal model	Male Sprague-Dawley rats (350-450 g)
	Dosages	30 mg/kg
	Administration	p.o.; per day for 7 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4543 mL	12.2713 mL	24.5427 mL	49.0854 mL
5mM	0.4909 mL	2.4543 mL	4.9085 mL	9.8171 mL
10mM	0.2454 mL	1.2271 mL	2.4543 mL	4.9085 mL
20mM	0.1227 mL	0.6136 mL	1.2271 mL	2.4543 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.